Triclabendazole 100mg Tablet For Deworm

Pharmacodynamics Triclobendazole belongs to the benzimidazole class of drugs, it is specially used to resist Fasciola hepatica, and has obvious killing effect on Fasciola hepatica of various ages. fluke medicine. After the drug is absorbed, it interferes with the microtubule structure and function of the parasite, Inhibits the release of parasite hydrolytic proteases. The effect of triclobendazole on worms varies with the concentration, such as adults at low concentrations (1 ~ 3μg/ml)

The drug still survives for 24 hours, and the activity is significantly weakened in the higher concentration (10-25μg/ml) for 24 hours; the high concentration of 25-50μg/ml completely inhibits it for 24 hours. But more sensitive to worms. At 10 μg/ml, all 24-hour activity was inhibited.

The bioavailability of triclobendazole is high. After oral administration of 10 mg/kg body weight in goats and sheep, the peak plasma drug reached 15 μg/ml in 24 to 36 hours, and the blood levels of triclobendazole and its metabolites were higher. The peak value of the drug is 5 to 20 times that of other benzimidazole anthelmintics, and the elimination half-life is about 22 hours. Triclobendazole is largely oxidized in sheep and rats to sulfone and sulfoxide derivatives, which bind to albumin and persist in plasma for more than 7 days. High plasma concentrations and binding to plasma albumin appear to be associated with prolonged duration of action of antifascioli. After 10 days of drug administration in sheep, about 95% of the drug is excreted in feces, 2% is excreted in urine, and less than 1% is excreted in milk.